Hello,
Sorry to hear you are having issues. Sad to see Groupy don't work for you because of Opera. Strange thing is Opera run great on my system too. What I do, it might help, might not. I turn off auto group on opera for my system.

Note: On this Sshot I have Opera on Windowblinds but I have problem "open in new tab". Once I exclude Opera.exe in my Windowblinds exclude list. Everything work normally.
Basj,
Stardock Community Assistant.