LokeYourLord...
Rereading the OP you say everything was fine with your system running DeskScapes....but you had some other issue that prompted you to 'uninstall with DDU' after which things went bad with DeskScapes' smooth running....
....but 'twiddling' settings had DeskScapes running again smoothly .... but only until a reboot - then everything went bad again.
As far as that goes it really sounds like an issue with your display driver install/setup, not with DeskScapes itself.
My suggestion would be to revert to the original driver that had no issues [unless that causes others]. It has NEVER been my experience that every new driver update was 100% perfect and/or desirable. It was often quipped that the name 'Detonator Drivers' was apt.
Modern updates have tended to be less drama...but they still arise....
Meanwhile...don't forget to email a ticket to support...