The 2010 Edition works great with x64, Jafo. I've been using it (x32) for a year or so, and it really is a superb piece of software.
Not to take the thread off track, but this is the 9.5 ver...[current]...for 64bit. The other File Managers are 32bit and often spit dummies saying 'not responding' while they cope...or try to.
As for 'power users'....we stuck with xtree...and more recently with ZtreeWIN. I've used alternate File Managers since first getting into Litestep - killing the explorer process meant not using it for ANYTHING....