Whoo hoo!!! 
Deskscapes is booting up and running in Windows 10 x64 reliably now. It no longer causes startup errors, etc. 
Bugs:
The multimonitor issues I mentioned in my previous posts remain.
Problem#1 - multimonitor ID mismatch between Deskscapes and Windows 10
For example, with three monitors, which Windows 10 labels as 3 1 2 with 1 being the primary in the middle, Deskscapes maps these monitors as 2 1 3 with regards to the configuration screen. This is, of course, confusing and may also have something to do with problem#2.
Note that these monitor and ID #'s match between Windows 10 and the Nvidia Control Panel.
I have included the Deskscapes About information below. I hope this helps to narrow down the issue.
Problem#2 - position of primary monitor and some DeskScapes dreams
If the leftmost monitor is not the Primary, Deskscapes has a problem running PhotoDream (for example) on the leftmost monitor until after the system is rebooted again. In fact, unless the leftmost monitor is the primary, DeskScapes has problems refreshing any change to the Dreams on any of the three monitors unless they are all video dreams as far as I can tell.
Curiously, if Dreams are assigned correctly (made complicated by the ID mismatch problem), a Restart of the system seems to be able to initialize the DeskScapes engine correctly and all Dreams play as expected. Just don't try to change them without expecting to reboot again, hehe.
I hope this bug report helps.
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DeskScapes appears to be activated on this PC
DeskScapes engine appears to be running
(Dell 3007WFP) 1 is attached to NVIDIA GeForce GTX 970 - This should actually be Monitor #3
(Dell 3008WFP(DP)) 2 is attached to NVIDIA GeForce GTX 970
(Dell U3011 (DP)) 3 is attached to NVIDIA GeForce GTX 970 - This should actually be Monitor #1
Deskscape.dll 2015/09/22 06:50:03
Deskscapes.dll 2014/03/10 08:45:52
DreamControl32.dll 2014/03/10 08:45:42
DeskscapesConfig.exe 2015/09/09 07:40:35
UI\Deskscape.dll 2015/09/09 07:38:38
UI\DeskscapesVideo.dll 2014/03/10 08:45:54
DreamTasks.exe 2014/03/10 08:45:58
DeskscapesVideo.dll 2014/03/10 08:45:22