It's the same one many are now reporting in the other thread. So far, it looks like at least a few of the people are on Vista 64.
"There was an error while applying {SKIN NAME}"
It fails with the default ones and any I create.
My system is Vista 64 Ultimate SP1, 8gb ram, quad core 6600 on a 680i series motherboard. This machine has multiple Operating Systems installed and this one boots off of the D: drive if that helps.