Ram drives are nice but situational.
Setting one up requires specific software for the task, and increases boot times.
If you play a particular, load intensive game, on a regular basis, it makes perfect sense. It also makes more sense if your computer is always on. I don't and I shut it down at night, so I've never gotten around to it despite having 32GB to play with.
If you're bottle necked by the drive and regularly use a particular program with heavy loading times, go for it. The software is cheap, the gains are utterly massive over a disk drive. Still massive over a fast SSD, but more like 10x than 50x.
There's also one area where the proper software would be... fantastic.
If you're one of those stupid schmucks that bought a 32-bit operating system because your brain didn't finish developing, you can use it to create a page file disk using extra ram your gimped piece of shit operating system can't access... Once you've got your just as fast as regular memory page file, 32-bit piece of shit operating system isn't so shit anymore. You have to be particular in software selection, RamDisk Plus is the only one I'm sure works this way.
I've got a few games I really like that get their panties in a twist over not having a page file, and paging a drive is a terrible thing to do to yourself, and the drive. I might actually do it one of these days just to end that crap.